CONJUGATE FROM MEDICAL COMPOUND AND DIPHOSPHONIC ACID DERIVATIVE

摘要

NEW MATERIAL:A compound of formula I (A-CO-is residue of the medical compound; R is -NH- or -O-; m is 0, 1; n is 1-10). EXAMPLE:Disodium salt of {alpha-(3',6'-dihydroxy-3-oxo-spiro[phthalane-1,9'- xanthene]-6-carbonyloxy)acetamidemethylene}bis(sulfonic acid). USE:Anti-inflammatory drugs. PREPARATION:A compound of formula A-COOH is reacted with a compound of formula II (OR1 is protected OH; Y is halogen) to form a compound of formu la III. This compound is then put to elimination of the protective group contained to obtain a compound of formula IV.