摘要 |
Phosphorylated plasminogen activator, such as phosphorylated prourokinase (pro-u-PA), which is substantially free from unphosphorylated plasminogen activator, may be obtained by phosphorylating unphosphorylated plasminogen activator with a phosporylating enzyme or by separating phosphorylated plasminogen activator from a mixture of phosphorylated plasminogen activator and unphosphorylated plasminogen activator. Phosphorylated pro-u-PA, which is substantially free from unphosphorylated pro-u-PA, is converted by plasmin into phosphorylated u-PA. The phosphorylated plasminogen activators such as phosphorylated pro-u-PA, u-PA and t-PA are useful as thrombolytic agents. |
申请人 |
BLASI, FRANCESCO;STOPPELLI, MARIA, PATRIZIA;MASTRONICOLA, MARIA, ROSARIA;WELINDER, KAREN, GJERSING;CORREAS, ISABEL |
发明人 |
BLASI, FRANCESCO;STOPPELLI, MARIA, PATRIZIA;MASTRONICOLA, MARIA, ROSARIA;WELINDER, KAREN, GJERSING;CORREAS, ISABEL |