发明名称 |
3-HYDROXYPYRIDINE. |
摘要 |
A compound of formula (1) <CHEM> and pharmaceutically acceptable acid addition salts thereof in which R<1> is hydrogen or can together with R<3> form a -(CH2)n- group where n is 2,3 or 4; R<3> is hydrogen, C1-4alkyl, halogen, or amino, or R<3> together with R<1> can form a -(CH2)n- group; R<4> is hydroxy or a phosphate group; R<5> is hydrogen, C1-4alkyl, halogen, or amino, provided that R<3> and R<5> are not both hydrogen; m is 2,3 or 4; and R is a 2, 3, or 4-pyridyl or pyridyl N-oxide or N-C1-C4alkylpyridone group optionally substituted by one or two groups selected from C1-4alkyl, C1-4alkoxy, hydroxy and hydroxymethyl. Also disclosed are pharmaceutical compositions containing compounds of formula (1), methods for their preparation and their use as histamine H1-antagonists. |
申请公布号 |
DE3765164(D1) |
申请公布日期 |
1990.10.31 |
申请号 |
DE19873765164 |
申请日期 |
1987.04.28 |
申请人 |
SMITH KLINE & FRENCH LABORATORIES LTD., WELWYN GARDEN CITY, HERTFORDSHIRE, GB |
发明人 |
COOPER, DAVID GWYN, LETCHWORTH HERTFORDSHIRE SG6 2SH, GB;MILES, PETER DONALD, LOWER STONDON BEDFORDSHIRE SG16 6JE, GB;YOUNG, RODNEY CHRISTOPHER, HERTFORD HERTFORDSHIRE SG14 1BH, GB |
分类号 |
A61K31/44;A61K31/4406;A61K31/4418;A61P11/00;A61P37/08;A61P43/00;C07D213/74;C07D401/14;C07D471/04;C07F9/58;(IPC1-7):C07D213/74;A61K31/675 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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