发明名称 |
Methods and compositions for the detection of familial hypercholesterolemia |
摘要 |
Recombinant DNA transfer vectors containing DNA inserts which are complementary to either the human LDL receptor gene, or its mRNA transcript, are disclosed. Also disclosed are methods which utilize these genetic probes for diagnosing Familial Hypercholesterolemia (FH) in a suspected individual. A case study of numerous such individual are disclosed wherein the genetic deletion mutation is detailed with great precision through the practice of this invention.
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申请公布号 |
US4966837(A) |
申请公布日期 |
1990.10.30 |
申请号 |
US19860925702 |
申请日期 |
1986.10.30 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
BROWN, MICHAEL S.;GOLDSTEIN, JOSEPH L.;RUSSELL, DAVID W. |
分类号 |
C07K14/705;C12Q1/68;G01N33/566;G01N33/92 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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