发明名称 |
PHENOLISCHE THIOAETHER ALS 5-LIPOXYGENASE-INHIBITOREN. |
摘要 |
The compounds of the present invention comprise substituted phenolic thioethers represented by the formula: <IMAGE> (I) wherein: R1 and R2 are the same or different and independently represent tert-alkyl or phenyl; A represents methylene or methylene substituted by alkyl, dialkyl or hydroxy, provided that when A includes hydroxymethylene, the hydroxymethylene group is not adjacent to a heteroatom; B represents sulfur, sulfoxide, sulfone, oxygen, -NH- or nitrogen substituted by alkyl, phenyl, benzyl, substituted phenyl or substituted benzyl; C represents methylene or methylene substituted by alkyl; R3 represents CO2H, CO2-alkyl or a tetrazole group; m is 0 or 1, n is 2, 3 or 4 and p is 1, 2 or 3; and the pharmaceutically acceptable salts thereof. The compounds of the present invention are specific inhibitors of 5-lipoxygenase and, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metabolic pathway are involved. |
申请公布号 |
DE3764976(D1) |
申请公布日期 |
1990.10.25 |
申请号 |
DE19873764976 |
申请日期 |
1987.01.29 |
申请人 |
G.D. SEARLE & CO., SKOKIE, ILL., US |
发明人 |
MUELLER, RICHARD AUGUST, GLENCOE, IL 60022, US;PARTIS, RICHARD ALLEN, EVANSTON, IL 60202, US;DEASON, JAMES DONALD, WILMETTE, IL 60091, US |
分类号 |
C12N9/99;A61K31/19;A61K31/195;A61K31/215;A61K31/22;A61K31/41;A61P11/00;A61P29/00;A61P37/08;A61P43/00;C07C67/00;C07C313/00;C07C317/22;C07C317/28;C07C317/44;C07C323/12;C07C323/20;C07C323/22;C07C323/25;C07C323/52;C07C323/65;C07C327/22;C07C331/08;C07C331/10;C07D257/04;(IPC1-7):C07C323/20;C07C317/14;C07C323/31;A61K31/395 |
主分类号 |
C12N9/99 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|