| 摘要 |
<p>Compounds of structure (I) <CHEM> in which R<1> is C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkylC1-6alkyl, phenyl(CH2)m the phenyl group being optionally substituted by 1-3 radicals selected from C1-6alkyl, C1-6alkoxy, amino C1-6alkylthio, halogen, cyano, hydroxy, carbamoyl, carboxy, C1-6alkanoyl and trifluoromethyl or Het(CH2)m in which Het is a 5 or 6 membered carbocyclic ring containing one or more heteroatoms and m is 0 to 6; R<2> is C1-6alkyl, phenyl, C1-6alkoxy, C1-6alkylthio, hydroxy, C1-6alkanoyl, amino, C1-6alkylamino, di-C1-6alkylamino, halogen, trifluoromethyl or cyano; R<3> is hydrogen or C1-4alkyl; n is 0, 1 or 2, and the dotted line indicates the optional presence of a double bond; processes for their preparation, pharmaceutical compositions containing them and their use in therapy as inhibitors of gastric acid secretion.</p> |
