ANGIOGENIC MONOBUTYRIN AND ITS ANALOGS

摘要

Monoglycerides of the formula: (1) wherein R is an aliphatic hydrocarbyl moiety of 2-10 C, straight chain or branched, saturated or unsaturated, and optionally substituted with one or more substituents which do not interfere with angiogenic activity are capable of stimulating angiogenesis in vivo. These compounds, and their pharmaceutical compositions, are useful in wound healing and other therapeutic applications where stimulation of vascularization is beneficial. Antibodies to these materials have also been prepared and are useful in diagnosis and therapy.