| 摘要 |
<p>NEW MATERIAL:A compound shown by formula I [Y1 is benzyl or alkyl which may be replaced; Y2 is amino-protecting group; Y3 is phosphonoprotecting group; Y4 is OH-protecting group; R1 is -COA1 (A1 is 1-30C alkyl which may be replaced with one or more OH groups protecting with OH-protecting group), etc.]. EXAMPLE:Methyl 2-deoxy-3-O-(N-dodeoancylglycyl)-2-(2,2,2- trichloroethoxycarbonylamino)-2-D-glucopyranoside. USE:An intermediate for an antitumor agent having beneficial physiological activity and low toxicity. PREPARATION:A compound shown by formula II is reacted with Y1OH in the presence of an acid and then with benzaldehyde in an organic solvent in the presence of D-camphor-10-sulfonic acid. Further the prepared compound shown by formula III is reacted with a compound shown by the R1OH, protecting group Q3 is removed and the resulting substance is reacted with a compound shown by formula IV (X3 is halogen) in the presence of a base in an organic solvent.</p> |
