COMPETITIVE GONADOLIBERIN ANTAGONIST

摘要

Peptides of the formula Ac-D-Nal(2)-D-Phe-D-Phe-Ser-X-D-Ser(Rha)-Leu-Arg-Pro-Y in which X represents Tyr or His and Y represents Gly-NH2, D-Ala-NH2, Azgly-NH2 or NH-C2H5 are competitive antagonists of Gn-RH. They are used for the treatment of gonadotropin- and steroid-dependent diseases and are prepared by known methods of peptide chemistry.