AEROSOLIZED AZOLE ANTIFUNGALS

摘要

There are described pharmaceutical formulations comprising as active ingredient, an azole antifungal in a form suitable for administration by inhalation. Such formulations include pressurised aerosol formulations, non-pressurised aerosol formulations and solutions/suspensions for use with a nebuliser device. Also described is finely divided powdered azole antifungal with a mass median diameter in the range 0.1 to 10 microns and a method of prophylaxis of a fungal pulmonary infection which comprises administering by inhalation a therapeutically effective amount of an azole antifungal to a patient predisposed to such an infection.