REGIOSELECTIVE SUBSTITUTIONS IN CYCLODEXTRINS

摘要

A process for preparing regiospecifically hydroxyalkylated alpha -, beta - or gamma -cyclodextrins wherein the substitution is either directed toward hydroxyls 2 or 2,3 of the glucose units with little substitution on hydroxyl 6 or toward hydroxyls 6 and with little substitution on the secondary hydroxyls. The regiospecificity is obtained through the proper control of basicity of the reaction mixtures which are comprised of epoxide and cyclodextrins and a suitable solvent.