| 摘要 |
To crystallize L- alpha -aspartyl-L-phenylalanine methyl ester from its aqueous solution by cooling, the initial concentration of the ester is adjusted so that the amount of precipitated solid phase formed after cooling is about 10 g or more per litre of the solvent, the solution is cooled by conductive heat transfer to form an apparently sherbet-like pseudo solid phase without effecting force flow by mechanical stirring or the like, and, if necessary, the system if further cooled after formation of the pseudo solid phase. Figures 1A and 1B are electron micrographs of crystals obtained by the process of the invention. |
