发明名称 Macrocyclic nitrogen ligands, method of preparation, metal complexes formed by the ligands, diagnostic and therapeutic compositions containing them.
摘要 <p>The invention relates to ligands having the formula (I), in which X represents a heterocyclic group, together with the process for their preparation. The invention also concerns mono- or polymetallic complexes formed by said ligands with metallic ions selected from lanthanide ions, transition metal ions, barium ion, bismuth ion, lead ion and the radioisotopes 99mTc, 111In, 90Y, 64Cu and 169Yb, as well as salts physiologically acceptable to these complexes. The salts of said complexes can be used as diagnostic and therapeutic agents in magnetic resonance imaging, radiology, in vivo chemical displacement agents and in nuclear medicine.</p>
申请公布号 EP0391766(A1) 申请公布日期 1990.10.10
申请号 EP19900400815 申请日期 1990.03.23
申请人 GUERBET S.A.;WAKE FOREST UNIVERSITY 发明人 JACKELS, SUZAN C.;MEYER, DOMINIQUE
分类号 A61K51/00;A61K49/00;A61K49/04;A61K49/06;A61K49/08;A61K51/04;C07D471/08;C07D471/18;C07D487/18;C07D498/18;C07D513/18 主分类号 A61K51/00
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