| 摘要 |
PURPOSE: To selectively inhibit the immune reaction controlled by the allelic gene by the immune tolerance induction of the peptide which contains an epitope structurally similar to the autoantigen relating to the autoimmune reaction and is coded by the MHC. CONSTITUTION: The antigen which identifies the allelic gene in the gene locus of MHC(major histocompatibility complex) which gives sensitivity to the autoimmune diseases and the allelic gene which gives the protective action to the autoimmune disease and is coded in the protective MHC type allelic gene and brings about the protective effect is given in an tolerance-inducing amount to prevent the autoimmune disease relating to the sensitive MHC type allelic gene. For example, in the prevention of insulin-dependent diabetes, a protective antigen coded in the protective HLA allelic genes DR2, DQ1 (Dw2), DR2 DQ1 (Dw12) or DR4 DQβ-3.1. is administered. |
