| 发明名称 |
GASTRIN-DISCHARGING PEPTIDE ANTAGONIST |
| 摘要 |
Small cell lung carcinoma (SCLC) cells contain gastrin releasing peptide (GRP) receptors. The response of the cells to GRP is rapid growth. We have found a group of peptide derivatives that act as GRP antagonists by blocking the binding of GRP to its receptor thereby inhibiting the growth of cells that are sensitive to the growth promoting activity of GRP. <CHEM> c |
| 申请公布号 |
JPH02250898(A) |
申请公布日期 |
1990.10.08 |
| 申请号 |
JP19890306764 |
申请日期 |
1989.11.28 |
| 申请人 |
MERCK & CO INC |
发明人 |
DEIBUITSUDO SHII HEIMUBURUTSUKU;MAAKU DABURIYU RIIMEN;AREN ORIFU;UORUFURETSUDO ESU SAARI |
| 分类号 |
A61K38/22;A61K38/00;A61P35/00;C07K1/02;C07K7/06;C07K14/575 |
主分类号 |
A61K38/22 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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