| 摘要 |
In the prepn. of effervescent tablets wet mixing and drying/ granulation are effected continuously in a sigle appts. Process comprises (a) premixing the reactants; (b) spraying with a liq. usually water, to 1-6% humidification the reactants being in an air- blown fluidised bed; and (c) drying, using the air from the fluidised bed, heated to 60-70 deg.C. This process may be carried out under a vacuum. The process is of partic. use in the prepn. of aspirin and paracetamol tablets. It allows the components to be combined under conditions such that the effervescence is controlled, is simple and has a high throughput. The process gives a very uniform prod.
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