AMINE DERIVATIVE AND ITS SALT AND ANTI-ULCER AGENT

摘要

N'-Methylsulphonyl-N"-furyl methylthio-ethyl-guanidine cpds. of formula (I) and their salts are prepared. R is 4-hydroxyphenyl, 4- carbamoylphenyl or 3-methanesulphonylaminophenyl. (I) are histamine H2 receptor antagonists, useful as antiulcer agents with better activity and stability and lower toxicity than known cpds. of JP 88458/84 and 97958/85. In mice all the cpds. had intravenous LD50 at least 0.1 g/kg. and the normal dose is 1 microg-10 mg/kg/ day in 1-4 portions.