发明名称 |
Production of interferon gamma |
摘要 |
Interferon gamma is produced in highly purified form (activity exceeding 108 units/ml-day) by CHO cells cotransformed by a first plasmid bearing the genomic human interferon gene under the control of the SV40 early promoter, and a second plasmid bearing a DHFR gene under similar control. Methotrexate selection yielded a clone which was a particularly efficient producer. Production of interferon gamma may also be facilitated by a Harvey sarcoma virus enhancer sequence.
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申请公布号 |
US4889803(A) |
申请公布日期 |
1989.12.26 |
申请号 |
US19850727673 |
申请日期 |
1985.04.26 |
申请人 |
YEDA RESEARCH & DEVELOPMENT CO., LTD. |
发明人 |
REVEL, MICHEL;RUBINSTEIN, MENACHEM;MORY, YVEZ |
分类号 |
C12N15/09;A61K38/21;C07H21/04;C07K1/22;C07K14/52;C07K14/555;C07K14/57;C07K16/00;C12N5/00;C12N5/10;C12N15/00;C12N15/23;C12N15/85;C12P21/00;C12P21/02;C12R1/91 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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