发明名称 |
USE OF CERTAIN HERBICIDES IN CANCER TREATMENT AND PRODUCTION OF PROTOPORPHYRIN IX |
摘要 |
Disclosed is a method and a pharmaceutical composition for killing mammalian tumor cells by subjecting said cells to light in the presence of a light-activatable tetrapyrrole, in which the improvement comprises treating said cells with a compound which inhibits the enzymatic conversion of protoporphyrinogen to protoporphyrin IX by protoporphyrinogen oxidase in said cells thereby causing a buildup of protoporphyrin IX in said cells. Also disclosed is a method for the production of protoporphrin IX which comprises growing eukaryotic microalgae in the presence of a protoporphrinogen oxidase inhibitor. |
申请公布号 |
WO9006748(A3) |
申请公布日期 |
1990.10.04 |
申请号 |
WO1989US05599 |
申请日期 |
1989.12.08 |
申请人 |
FMC CORPORATION |
发明人 |
HALLING, BLAIK, PHILLIP;WITKOWSKI, DEBRA, ANN |
分类号 |
C12P1/00;A61K31/00;A61K31/24;A61K31/395;A61K31/40;A61K31/403;A61K31/4035;A61K31/41;A61K31/415;A61K31/4245;A61K31/44;A61K31/50;A61K31/53;A61K31/535;A61K41/00;A61K45/00;A61P31/04;A61P35/00;A61P43/00;C07D209/48;C07D231/38;C07D231/54;C07D231/56;C07D271/10;C07D403/04;C07D413/04;C07D417/12;C07D487/22;C12R1/89 |
主分类号 |
C12P1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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