ANGIOGENIC BUTYRIC ACID ANALOGS AND THEIR PRODRUGS

摘要

Butyric acid and its analogs of formula (1) or the physiological salts thereof, wherein each X2, X3 and X4 is independently H, OH, OR, SH, SR, NH2, NHR, NR2, or halo, wherein each R is independently lower alkyl(1-4C); or one or two of X3 and X4 taken together form a pi-bond, or wherein one of X2 and X3 taken together form a pi-bond; with the proviso that at least four of said X must be either H or a participant in a pi-bond, or a prodrug which generates said compound of formula (1) or its salt, are capable of stimulating angiogenesis in vivo. These compounds, and their pharmaceutical compositions, are therefore useful in wound healing and other therapeutic applications where stimulation of vascularization is beneficial. Antibodies to these materials have also been prepared and are useful in diagnosis and therapy.