| 摘要 |
The invention relates to the pyrrolyl-substituted hydroxamic acid derivatives of the formula <IMAGE> (I) wherein R represents aryl, aryl-lower alkyl, cycloalkyl, bicycloalkyl or adamantyl; R1 and R2 represent hydrogen or lower alkyl; Y represents a direct bond, lower alkylene, lower alkenylene or lower alkadienylene; Z represents <IMAGE> (a) wherein R3 represents hydrogen or acyl; R4 represents lower alkyl, C3-C7-cycloalkyl, aryl or aryl-lower alkyl; or Z represents <IMAGE> (b) wherein R3 represents hydrogen or acyl; R5 represents lower alkyl, C3-C7-cycloalkyl, aryl, aryl-lower alkyl, amino or N-(mono- or di-lower alkyl)-amino; R6 and R7 represent hydrogen or lower alkyl; and pharmaceutically acceptable salts thereof provided that R3 represents hydrogen; which are useful as lipoxygenase inhibitors.
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