Process for the manufacture of alkynediols by reaction of ketones with acetylene

摘要

A process for manufacturing an alkynediol is disclosed. In this process, a C3-12 ketone is reacted with acetylene in the presence of potassium hydroxide in an C1-4 alkyl-tert-butyl ether solvent. The potassium hydroxide is used in a molar ratio, relative to the amount of ketone used, of from 1.0:1.0 to 1.6:1.0.