HUMAN MONOCLONAL ANTIBODY REACTIVE WITH E SERUM-TYPE PSEUDOMONAS AERUGINOSA, CELL CAPABLE OF PRODUCING SAME, ITS PRODUCTION AND PHARMACEUTICAL

摘要

PURPOSE:To provide human-human hybridoma and cell strain stemmed therefrom, capable of stably producing in relatively large quantities human monoclonal antibody reactive with E serum-type Pseudomonas aeruginosa. CONSTITUTION:For example, using, as parent cell strain, infinitely reproductive cell strain having only human chromosome and resistant to both 8-azaguanine and ouabain, and using, as human antibody-productive cells, Epstein-Barr virus transformant cells reactive with E serum-type Pseudomonas aeruginosa, the objective human-human hybridoma (FERM P-2272, 2273) is prepared.