PROCESS FOR THE PREPARATION OF NEW THIENYL-OXY-ALKYL-AMINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

PCT No. PCT/AT89/00084 Sec. 371 Date May 15, 1990 Sec. 102(e) Date May 15, 1990 PCT Filed Sep. 12, 1989 PCT Pub. No. WO90/02743 PCT Pub. Date Mar. 22, 1990.Thienyloxyalkylamine derivatives of the general formula: I wherein -O-CH2-CH2-NR2R3 is in position 4 or 5 of the thiophene ring; R1 is hydrogen, halogen, CF3, alkyl or alkoxy; R2 and R3 are the same or different and are each alkyl, cycloalkyl, alkenyl or alkynyl each having up to 8 C atoms, or NR2R3 is a 5 to 7-membered saturated heterocyclic ring optionally containing a further hetero atom which is oxygen or nitrogen optionally substituted by an alkyl group having 1 to 3 C atoms; and n is an integer of 1 to 5; as well as their acid addition salts, are suitable for treatment of heart rhythm disturbances.