| 摘要 |
Heterocyclicguanidines as 5HT3 antagonists useful in the treatment of nausea, anxiety, pain, schizophrenia and gastrointestinal disorders, of the formula <CHEM> and their pharmaceutically acceptable acid addition salts, wherein Ar is naphthyl, indol-3-yl, 2-methyl-indol-3-yl, 1-methylindol-3-yl, 1-benzylindol-3-yl, phenyl, or mono- or disubstituted phenyl wherein said substituent is each methyl, methoxy, chloro, fluoro or bromo; Het is thiazolyl, furyl, thienyl or isoxazolyl, R1 is hydrogen or methyl; R2 and R3 when considered separately are each hydrogen, hydroxyethyl, alkyl having one to six carbon atoms, cycloalkyl having three to six carbon atoms or acetyl; and R2 and R3 when taken together are alkylene having two to three carbon atoms. |
