Process for the preparation of 2'-deoxy-5-trifluoromethyl-beta-uridine.

摘要

The present invention is a process for the preparation of 2 min -deoxy-5-trifluoromethyl- beta -uridine characterized in that a 5-trifluoromethyyl-2,4-bis(triorganosilyloxy)pyrimidine and a 1-halogeno-2-deoxy-alpha-D-erythro-pentofuranose derivative are subjected to a condensation reaction to give a 1-(2-deoxy- beta -D-erythro-pentofuranosyl)-5-trifluoromethyluracil derivative which is then subjected to a deprotection reaction to give 2 min -deoxy-5-trifluoromethyl- beta -uridine.