发明名称 |
IL-1 BIOLOGICAL ACTIVITY INHIBITORS |
摘要 |
Disclosed are novel muteins of IL-1 compounds which can be used to regulate excess IL-1 produced in various diseases in humans and animals. The IL-1 muteins can be prepared by site-directed mutagenesis whereby a positively charged residue is replaced with a negatively charged or neutral residue at a designated position in the molecule. The resulting IL-1 muteins have reduced biological activity but retain receptor binding affinity. |
申请公布号 |
AU5171890(A) |
申请公布日期 |
1990.09.26 |
申请号 |
AU19900051718 |
申请日期 |
1990.02.23 |
申请人 |
NEW ENGLAND MEDICAL CENTER HOSPITALS, INC. |
发明人 |
LEE GEHRKE;PHILIP E. AURON;LANNY ROSENWASSER |
分类号 |
C12N15/09;A61K38/00;A61P29/00;C07K14/435;C07K14/52;C07K14/545;C12N15/25;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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