| 摘要 |
NEW MATERIAL:A compound shown by the formulaI(R is H, alkyl, alkenyl, or aryl; R<1> and R<2> are H or alkyl, or R<1> and R<2> form alkylene or polymethylene. EXAMPLE:3-Acetoxy-2,2-dimethyl-5-phenyl-1-oxa-3-cyclopentene. USE:A precursor for synthesizing geiparvarin having a carcinostatic action in high selectivity in high yield and a precursor for synthesizing a carcinostatic substance or antibiotic such as ascofuranone, etc. having a tetrahydrofuranone structure. PROCESS:A 2-butyne-1,4-diol derivative shown by the formula II is reacted with acetic anhydride in the presence of a base, to give a 2-butyne-1,4-diol monoacetal derivative shown by the formula III, which is subjected to ring formation in the presence of a copper (I) catalyst such as AgClO4, etc., to give a compound shown by the formulaI. |
