5 s penem derivatives, their preparation and use

摘要

The use of a 5S penem compound of general formula (I) wherein n is 0 or 1, R2 is hydrogen or a substituent group, R3 is an ester- or amide-forming group, and R1 is hydrogen or an organic group linked via carbon and wherein the group -COR3 is substantially stable toward in-vivo hydrolysis, in the form of its 5S isomer, as an inhibitor of the bacterial enzyme leader peptidase 1.