发明名称 |
PREPARATION OF OPTICALLY ACTIVE 3-THIOLANYL SULFONATE |
摘要 |
Intermediates and a stepwise process for the conversion of an alkyl 4-chloro-3R-hydroxybutyrate to optically active compounds of the formula <CHEM> wherein R is (C1-C3)alkyl, phenyl or tolyl. The latter compounds are in turn useful as an intermediate in the preparation of penem antibiotic 5R,6S-6-(1R-hydroxyethyl)-2-(1R-oxo-3S-thiola nylthio)-2-penem-3-carboxylic acid and corresponding pharmaceutically acceptable salts and esters. |
申请公布号 |
JPH02240077(A) |
申请公布日期 |
1990.09.25 |
申请号 |
JP19900031313 |
申请日期 |
1990.02.09 |
申请人 |
PFIZER INC |
发明人 |
ROBAATO ARUFURETSUDO FUORUKUMAN |
分类号 |
C07C31/42;C07C309/06;C07C309/65;C07C309/73;C07D333/32 |
主分类号 |
C07C31/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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