SEQUENCING NUCLEIC ACIDS USING CHEMILUMINESCENT DETECTION
摘要
This invention pertains to methods of detecting nucleic acids by chemiluminescence and to methods of sequencing nucleic acids using chemiluminescence detection. Nucleic acids are covalently or non-covalently linked to a compound that can generate chemiluminescence. Preferably the nucleic acid is linked to an enzyme and the substrate for the enzyme is a stable but enzymatically triggerable substituted 1,2-dioxetane.
申请公布号
WO9010718(A1)
申请公布日期
1990.09.20
申请号
WO1990US01316
申请日期
1990.03.09
申请人
MILLIPORE CORPORATION
发明人
BECK, STEPHAN;COULL, JAMES, M.;KOESTER, HUBERT;O'KEEFFE, THOMAS, J.