Envelope antigens of the human immuno-deficiency virus, and their applications.

摘要

The invention concerns purified expression products of DNA sequences derived of the genome of the LAV virus. It relates more particularly to a glycoprotein having a molecular weight of about 110,000 or antigen of lower molecular weight derived from the preceding one, which purified product possesses the capacity of being recognised by serums of human origin and containing antibodies against the LAV virus. It also relates to other purified polypeptides derived either from the abovesaid glycoprotein or of core proteins of LAV virus. The glycoprotein can be used for the production of immunogenic composition capable of neutralizing the LAV virus. All of the abovesaid glycoprotein or polypeptides can be used as antigens useful in the diagnosis of LAV antibodies in sera of patients.