| 发明名称 |
INHIBITION OF HIV USING SYNERGISTIC COMBINATIONS OF NUCLEOSIDE DERIVATIVES |
| 摘要 |
The present invention relates to the use of synergistic combinations of nucleoside derivatives for inhibiting human immunodeficiency virus (HIV) replication, thereby limiting HIV infection. In a particular embodiment, the purine nucleoside analogue dideoxyinosine combined with the pyrimidine nucleoside analogue 2',3'-dideoxy-2',3'-didehydrothymidine (d4T) exhibit strong synergistic activity and diminished cytotoxic activity toward mammalian cells.
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| 申请公布号 |
CA2050473(A1) |
申请公布日期 |
1990.09.18 |
| 申请号 |
CA19902050473 |
申请日期 |
1990.03.16 |
| 申请人 |
ONCOGEN LIMITED PARTNERSHIP |
发明人 |
BRANKOVAN, VERA;WHITE, RICHARD J. |
| 分类号 |
A61K31/505;A61K;A61K31/52;A61K31/522;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7076;A61K31/708;A61K39/21;A61K45/06;A61P31/12;A61P43/00;C07D405/04;C07D473/30;C07D473/34;C07H;C07H19/00;C07H19/04;C07H19/06;C07H19/16;C12N;C12N7/00;C12N7/06;C12N9/00;C12N15/00;(IPC1-7):A61K31/70 |
主分类号 |
A61K31/505 |
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