| 摘要 |
PURPOSE: To prepare a liquid pharmaceutical composition, comprising a piperidinoalkanol, a buffer such as gluconic acid and water and enabling the efficient immediate absorption after oral administration and utilization for organisms. CONSTITUTION: This liquid pharmaceutical composition comprises about 2-25mM piperidinoalkanol useful as an antihistaminic agent, a antiallergic agent and a bronchodilator, e.g. a compound represented by formula I [R1 is H or OH; R2 is H; R1 and R2 together may form a bond; (n) is 1-3; Z is thienyl or a (substituted)thienyl] or formula II [(m) is 1-5; R3 is CH3 or CH2 OH; A and B are each H or OH], (B) about 0.001-0.5M suitable buffer selected from the group consisting of gluconic acid, lactic acid, citric acid and acetic acid and (C) about 5-99wt.% water.α-[4-(1,1-Dimethylenthyl) phenyl]-4-(hydroxydiphenylmethyl)-1piperidinebutanol is preferred as the ingredient A.
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