PROCESS FOR PREPARATION OF POLYPEPTIDE

摘要

A synthetic peptide of the formula (I) or a biologically active fragment or a non-toxic salt or such a peptide is prepd.. H-Tyr-Ala- Asp-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-LeuSer-Ala-Arg- Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Glu-Gly-GluR34-Asn-Gln-Glu- R38-Gly-R4S0-R4S1-R (I). R is OH or amino; R34 is Ser or Ala; R38 is Arg or Ser; R40 is Ala or Arg; and R41 is Arg, Arg-Als, Arg-Ala-Arg, Arg-Ala-Arg-Leu or des-R41. (I) and fragments promote the release of growth hormone from the pituitary. They can be used to treat 'pituitary-dwarfs'.