发明名称 |
NEW MICROBIAL IMMUNOREGULANT |
摘要 |
7410P/5413A 3/14/89:Fl 17888 TITLE OF THE INVENTION NEW MICROBIAL IMMUNOREGULANT Described is a new immunosuppressant, L-687,819, a C-31 demethylated derivative of L-683,795 (FK-523), produced under fermentation conditions utilizing the new mutant microorganism, Streptomyces hygroscopicus subsp. ascomyceticus (Merck Culture Collection MA 6646) ATCC No. 53855, being a blocked mutant of Streptomyces hygroscopicus subsp. ascomyceticus (MA 6475) ATCC No. 14891. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
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申请公布号 |
CA2012275(A1) |
申请公布日期 |
1990.09.15 |
申请号 |
CA19902012275 |
申请日期 |
1990.03.15 |
申请人 |
MERCK & CO., INC. |
发明人 |
KAPLAN, LOUIS;BORRIS, ROBERT P.;BYRNE, KEVIN M.;WICKER, LINDA S.;ZINK, DEBORAH L. |
分类号 |
C12P17/16;A61K31/445;A61P37/00;A61P37/06;C07D498/18;C07H19/01;C12P17/18;C12P19/44;C12R1/55;(IPC1-7):C07H17/00;A61K31/455 |
主分类号 |
C12P17/16 |
代理机构 |
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代理人 |
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地址 |
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