<p>The present invention provides novel renin-inhibiting peptides having a noncleavable transition state insert corresponding to the 10,11- position of the renin substrate (angiotensinogen) and a polyhydroxy-substituted alkyl moiety bonded directly through carbon or nitrogen to the N-terminus. Such inhibitors are useful for the diagnosis and control of renin-dependent hypertension and other related diseases.</p>
申请公布号
DK183090(A)
申请公布日期
1990.09.14
申请号
DK19900001830
申请日期
1990.07.31
申请人
UPJOHN COMPANY, THE
发明人
BUNDY, GORDON L.;THAISRIVONGS, SUVIT;NELSON, NORMAN A.;HESTER, JR., JACKSON B.;FISHER, JED F.;LIPTON, MICHAEL F.
