发明名称 |
Process for producing 4-(2-methoxyethyl)-phenyl-glycidyl ether and/or metoprolol |
摘要 |
A process for the preparation of metoprolol in a stereospecific form or a non-toxic, pharmaceutically acceptable acid addition salt thereof and/or a stereospecific form of 4-(2-methoxyethyl)-phenyl glycidyl ether which comprises subjecting 4-(2-methoxyethyl)-phenyl allyl ether to the action of a microorganism having the ability for stereoselective epoxidation of 4-(2-methoxyethyl)-phenyl allyl ether into 4-(2-methoxyethyl)-phenyl glycidyl ether having at least 80% by weight the S configuration, at least partly separating 4-(2-methoxyethyl)-phenyl glycidyl ether and/or reacting 4-(2-methoxyethyl)-phenyl glycidyl ether with isopropylamine and at least partly separating metoprolol and/or converting metoprolol into its non-toxic, pharmaceutically acceptable acid addition salt.
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申请公布号 |
US4956284(A) |
申请公布日期 |
1990.09.11 |
申请号 |
US19860826791 |
申请日期 |
1986.02.06 |
申请人 |
GIST-BROCADES N.V. |
发明人 |
PHILLIPS, GARETH T.;ROBERTSON, BRIAN W.;BERTOLA, MAURO A.;KOGER, HEIN S.;MARX, ARTHUR F.;WATTS, PETER D. |
分类号 |
C07C213/04;C07D303/24;C12P17/02 |
主分类号 |
C07C213/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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