Stimulation of tear secretion with cyclic nucleotides

摘要

A method and preparation for the stimulation of tear secretion. The method involves topically applying a phosphodiesterase inhibitor and/or cyclic nucleotide analogue to the ocular surface. Inhibition of phosphodiesterase and cyclic nucleotide analogues increase cyclic nucleotide levels in lacrimal gland tissue, thereby stimulating tear secretion. The preparation contains a phosphodiesterase inhibitor or a cyclic nucleotide analogue and a vehicle for the phosphodiesterase inhibitor or cyclic nucleotide analogue, and may contain an ophthalmic preservative.