| 摘要 |
Various metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5] decane-7,9-dione which are particularly useful in the treatment of psychotic disorders, especially derivatives thereof which have been oxygenated at specified sites about the original structure, rearranged compounds, and prodrug formulations of these species. One particularly desired group of compounds have the general Formula I where <IMAGE> I R1 is hydrogen, hydroxyl, alkoxy, acyloxy and oxo; R2 is hydrogen, methyl, hydroxyl, alkoxy, and acyloxy; R3 is hydrogen, hydroxyl, and methoxy: R4 is hydrogen, methyl and oxo; and X is S, SO, and SO2.
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