发明名称 |
Process for the preparation of rooperol derivative |
摘要 |
A process for preparing a compound of the formula <IMAGE> in which both Rs and H or OH; comprising the steps a. of treating the ethyl ester of caffeic acid with trialkylsilyl chloride at ambient conditions in equimolar proportions in the presence of a base; b. the reduction of the ester to the corresponding allylic alcohol with aluminum hydride reagent; c. of oxidizing the resulting product with manganese dioxide at ambient temperature and in excess molar proportion to yield the corresponding allylic aldehyde; d. of coupling the latter with the silyl ether of the relative phenyl acetylide; and e. of hydrolysis of this coupled product with alkylammonium fluoride at ambient conditions in equimolar proportions.
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申请公布号 |
US4956502(A) |
申请公布日期 |
1990.09.11 |
申请号 |
US19890365494 |
申请日期 |
1989.06.13 |
申请人 |
ROOPEROL (N.A.) NV |
发明人 |
WENTELER, GEORGE L.;REGEL, KARL H.;DREWS, SIEGFRIED;KUNDIG, HANS |
分类号 |
C07C39/21;C07F7/18;C07H15/203 |
主分类号 |
C07C39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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