Decahydro-8H-isoquino(2,1-g)(1,6)naphthyridine derivatives and related compounds

摘要

Compounds of formulas (1) and (2): <IMAGE> (1) <IMAGE> (2) in which: X and Y are independently hydrogen, hydroxy, lower alkyl, lower alkoxy or halo, or X and Y taken together is methylenedioxy or ethylene-1,2-dioxy; W is oxygen or sulfur; and Z is -R1, -OR2 or -NR3R4, wherein R1 is lower alkyl, lower haloalkyl, cycloalkyl, optionally substituted phenyl or phenyl lower alkyl, or heteroaryl; R2 is lower alkyl, optionally substituted phenyl or phenyl lower alkyl; R3 and R4 are independently hydrogen, alkyl, optionally substituted phenyl or phenyl lower alkyl; or R3 and R4 taken together with the nitrogen to which they are attached represent a heterocycle of the formula: <IMAGE> wherein A is -(CH2)m, -N(R5)- or oxygen, in which m is an integer of 0-2 and R5 is hydrogen or lower alkyl; or a pharmaceutically acceptable salt thereof, are useful as alpha 2-blockers.