| 摘要 |
<p>Novel N-(piperidinyl-alkyl)-carboxamides The invention relates to novel N-(piperidinyl-alkyl)-carboxamides of the general formula (I) in which R represents hydroxy, hydroxy etherified by an aliphatic alcohol, or halogen, Ar1 represents a monocyclic arylene or heteroarylene radical, alk represents an alkylene group that separates the two N atoms by at least two carbon atoms, X represents a free or ketalised carbonyl group, free hydroxymethylene or hydroxymethylene esterified by an organic carboxylic acid, or methylene, and Ar2 represents a monocyclic aryl or heteroaryl radical, and salts thereof, with the proviso that the grouping R-Ar1 is other than a radical of the formula (Ia) in which R1 is selected from the group consisting of lower alkyl, trifluoromethyl, halogen, lower alkoxy, nitro and cyano and at least one of the radicals R1 represents halogen or lower alkoxy, n represents an integer from 1 to 3, and Z represents nitro, amino, lower alkylamino, arylamino, aryl-lower alkylamino, (thio-)formylamino, (thio-)lower alkanoylamino, (thio-)aroylamino or aryl-(thio-)lower alkanoylamino, if alk and X have the meanings given and Ar2 represents unsubstituted phenyl, thienyl or pyridyl or substituted phenyl having one, two or three substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy, trifluoromethyl and amino, and to processes for the manufacture thereof. The compound of formula (I) exhibit valuable pharmacological properties, in particular a pronounced antipsychotic action.</p> |
