发明名称 |
MOLECULAR CLONING OF GENOMIC AND CDNA SEQUENCES ENCODING CELLULAR RECEPTORS FOR POLIOVIRUS |
摘要 |
2048993 9010699 PCTABS00002 The subject invention provides an isolated nucleic acid molecule which comprises nucleic acid encoding a polypeptide which has the biological activity of a receptor for picornavirus and in addition, provides a purified polypeptide which has this activity. The subject invention also provides a method for inducing the production of a polypeptide which includes the use of expression vectors in a host vector system. Therapeutic compositions comprising purified polypeptides which have the biological activity of a receptor for picornavirus are also provided for as are methods of treating and preventing human poliovirus infection. Further, the subject invention provides a method of producing a transgenic animal expressing human picornavirus. The subject invention provides a method of testing the efficacy of a picornavirus vaccine which comprises administering the vaccine to a transgenic animal described above and determining whether the resulting transgenic animal is protected from infection by human picornavirus. Lastly, a method of testing the virulence of a picornavirus vaccine is provided.
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申请公布号 |
CA2048993(A1) |
申请公布日期 |
1990.09.11 |
申请号 |
CA19902048993 |
申请日期 |
1990.03.09 |
申请人 |
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (THE) |
发明人 |
RACANIELLO, VINCENT;MENDELSOHN, CATHY;COSTANTINI, FRANK |
分类号 |
A01K67/027;A01K67/02;A61K35/76;A61K38/00;A61K39/00;A61K39/125;A61K39/13;A61K39/395;A61K47/48;A61K49/00;A61P31/12;C07H21/04;C07K14/00;C07K14/705;C07K16/00;C07K16/28;C12N1/11;C12N1/21;C12N15/09;C12N15/12;C12N15/85;C12P21/02;C12R1/19;(IPC1-7):C12N15/12;A61K38/17 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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