SOLUBILIZATION OF INDOMETHACIN AND PIROXICAM BY A QUATERNIZED POLYMER

摘要

A method for increasing the water-solubility of indomethacin or piroxicam by forming a complex product from the reaction between the indomethacin or piroxicam and an aqueous solution of a solid quaternized organic compound. The solubility of the indomethacin or piroxicam can be increased at least 25-fold, and the complex formed is highly stable at ambient conditions.