发明名称 |
BONE COLLAGEN MATRIX FOR IMPLANTS |
摘要 |
A matrix for implantation in a mammalian host comprising biocompatible, mineral-free, insoluble Type-I bone collagen which may be allogenic or xenogenic to the host, and which, when implanted in the host, is biodegradable. The collagen is treated with a collagen fibril modifying substance such as acidified acetonitrile, chloroform, or dichloromethane, or by heating in an aqueous environment to a temperature of 37 DEG -65 DEG C. The treated material undergoes a change in morphology involving a significant increase in its surface area as measured by various methods. Under the scanning electron microscope the material has an ''oyster shell'' appearance with many pits and micropores. |
申请公布号 |
WO9010018(A1) |
申请公布日期 |
1990.09.07 |
申请号 |
WO1990US00912 |
申请日期 |
1990.02.22 |
申请人 |
CREATIVE BIOMOLECULES, INC. |
发明人 |
KUBERASAMPATH, THANGAVEL;RIDGE, RICHARD, J. |
分类号 |
A61L27/00;A61C8/00;A61F2/00;A61K9/00;A61K38/00;A61K38/17;A61L27/22;A61L27/24;A61L27/34;A61L27/36;A61L27/56;A61P43/00;C07K14/51;C07K14/78;C08H1/00;C09H1/00;C09H1/02 |
主分类号 |
A61L27/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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