| 摘要 |
<p>A method of delivering a drug through the skin of an animal comprising applying an enzyme preparation to a localized area of the skin for a predetermined amount of time and in a sufficient quantity to alter the structure of the localized area of skin; occluding the localized area of skin with occlusion means (20) during said predetermined amount of time; removing said occlusion means (20) and applying an effective amount of the drug to the localized area of the skin. Also disclosed is a percutaneous drug delivery system comprising contact means (30) for contacting an enzyme preparation to a localized area of skin; means for occluding said localized area of skin in contact with said contact means (30); and means (32) for applying a drug to said localized area of skin after said contact means and said occlusion means have been removed from said localized area of skin, wherein said contact means and said means for applying a drug are different patches (30, 32). Further disclosed is a method of delivering a drug through the skin of an animal comprising applying a percutaneous permeation enhancer comprising effective amounts of a combination of enzymatic and non-enzymatic permeation enhancers to a localized area of the skin of said animal for a predetermined amount of time and in a sufficient quantity to enhance the permeability of the localized area of skin to the drug; occluding the localized area of skin with occlusion means (20) during said predetermined amount of time; removing said occlusion means (20); and applying an effective amount of the drug to the localized area of skin so that at least some of the drug permeates through the skin.</p> |
