HENYL DERIVATIVES AND AZACYCLOOCTADIENE DERIVATIVES

摘要

An azacyclooctadiene compound having the formula (1) or a pharmacologically acceptable salt thereof is novel and useful as an anti-tumor agent. in which R1 is -CH2R, R being hydrogen, -COCH3, -OH, -NH2, -COOH or -OCOCH3, or may form -CH2-X-Y- together with R2; R2 is hydrogen, an alkyl having 1 to 4 carbon atoms or -COR10, R10 being hydrogen, an alkyl having 1 to 4 carbon atoms, -OR11 or -NHR11, R11 being an alkyl having 1 to 4 carbon atoms, or may form -CH2-X-Y- together with R1; R3, R4 and R5 each are hydrogen or methyl; R6 and R7 each are hydrogen or may form the direct bond to each other; R8 is hydrogen or may form the direct bond to R7; and R9 is hydrogen, -N3, -NH2, -OCH3 or =O; X being oxygen or -NZ-, Z being hydrogen, methyl; -COCH3, -CH2COOH, -CO-CH=CH2, -CO-CH=CH-CH3, -CH2C6H5, -CH2OH, -CH2OCOCH3 or -CH2-COOC(CH3)3, Y being -CS-, -CO- or -CH2-.