SECO-NUCLEOSID-DERIVATE, VERFAHREN ZU DEREN HERSTELLUNG SOWIE DEREN VERWENDUNG ALS ANTIVIRALE MITTEL

摘要

The invention concerns novel seco-nucleoside derivatives of general formula (I), where R is hydrogen, an aliphatic acyl group with 1 to 20 atoms or a monophosphate, diphosphate or triphosphate group, R<1> is a C1 to C7 alkyl, halogen C1 to C7 alkyl, trifluormethyl, C2 to C7 alkenyl, C3 to C7 alkandienyl, C2 to C7 alkinyl, cyano, formyl, C1 to C7 alkyl carbonyl, C1 to C7 alkoxycarbonyl, aminocarbonyl, azido, C3 to C7 cycloalkenyl or aryl group or a saturated, unsaturated or aromatic heterocycle, and R<2> is a thymine, uracil, cytosine, adenine, hypoxanthine or guanine group, whereby a) R cannot be a hydrogen atom or an acyl group if R<1> is an alkyl, cycloalkyl or phenyl group and R<2> is a uracil or thymine group, and b) R cannot be a hydrogen atom or an acyl group if R<1> is an alkyl group and R<2> is an adenine, guanine or hypoxanthine group. The invention also concerns their tautomers, optically active forms or physiologically acceptable salts of inorganic and organic acids and bases, as well as processes for manufacturing them and drugs containing these ccompounds.