| 摘要 |
The invention relates to novel acyl derivatives of rifamycins of the formula <IMAGE> and their salts, in which the structural elements -A1-A2-, -A3-A4- and -A5-A6- each denote ethylene or vinylene or the elements -A1-A2- and -A3-A4- each denote ethylene and -A5-A6- denotes vinylene; X stands for <2bL>C(R6)- or <2bL>N- and R6 denotes hydrogen or alkyl; alk denotes an aliphatic hydrocarbon radical; R1 denotes hydrogen or acyl; R2 denotes acyl and R3 and R3' stand for a common bond or R3 denotes hydrogen or acyl and R3' is hydrogen; R4 denotes hydrogen, cycloalkyl or aryl; R5 denotes hydrogen or acetyl; R7 denotes hydrogen or alkyl, which can be used as pharmaceutical active substances, their preparation and use and pharmaceutical preparations and their production. |
